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This press release was released prior to the formation of Supernus Pharmaceuticals.

Press Release
FOR IMMEDIATE RELEASE
27 November, 2001
CONTACT:
Woody Bryan, PhD.
Tel +1 301 838 2681

 
Shire Laboratories receives US Patent # 6,322,819 on oral pulsed dose drug delivery system

   ROCKVILLE, MD - (27 November, 2001) - Shire Laboratories, Inc. announced today that the US Patent and Trademark Office has issued US Patent # 6,322,819 for the company's oral pulsed dose drug delivery system.

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   THE "SAFE HARBOR" STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995. The statements in this press release that are not historical facts are forward-looking statements that involve risks and uncertainties, including but not limited to, risks associated with the inherent uncertainty of pharmaceutical research, product development and commercialization, the impact of competitive products, patents, and other risks and uncertainties, including those detailed from time to time in periodic reports, including the F-4 Prospectus and the Annual Report filed on Form 20-F with the Securities and Exchange Commission.