Cells in the brain communicate with each other via electric signals and by using messenger substances, called "neurotransmitters." If there are too few neurotransmitters, communication is disrupted, which causes the symptoms of depression and anxiety.

Depression strikes people of all ages, backgrounds, and ethnic groups.

Depressive disorders affect about 34 million American adults.

Depression Programs

SPN809:

• NCE - First in US.
  
• Same indication as previously marketed in the EU.
  
• Additional new CNS indication is being pursued.
  
• IND filing in 2008.
  
• Phase I is targeted to start in 2008.