Epilepsy is a neurological condition which affects the nervous system and is also known as a seizure disorder. It is usually diagnosed after a person has had at least two seizures that were not caused by some known medical condition like alcohol withdrawal or extremely low blood sugar. A seizure is defined as an abnormal, disorderly discharging of the brain's nerve cells, resulting in a temporary disturbance of motor, sensory, or mental function.

About 2.7 million Americans have been treated for epilepsy in the past 5 years. That's 8 or 9 out of every 1,000 people.

Epilepsy Programs

SPN804 (Oxcarbazepine QD):

• Oxcarbazepine worldwide sales of $721MM in 2006.
  
• Supernus has completed single dose and multi-dose steady state PK studies demonstrating once per day dosing.
  
• Supernus program is targeted to enter Phase III in 2008.
  

SPN538 (Topiramate QD):

• Topamax worldwide sales of >$2 billion.
  
• Supernus has completed single dose and multi-dose steady state PK studies demonstrating once per day dosing.
  
• Supernus program is targeted to enter Phase III in 2009.